October 04, 2014 10:00 pm


For a while now, I have been intrigued by the CYP450 medication, inflammation, and histamine connection. Understanding this relationship has been essential in my journey to health.

My own experience with mast cell activation began after being prescribed CYP450-mediated medication, particularly those related to CYP2D6.

I discovered a CYP2D6 genetic mutation that triggered oxidative stress and chronic inflammation, resulting in an elevated C-reactive protein level.

Histamine intolerance and mast cell activation can stem from various causes, and my story is just one among many. However, medication intolerances are notably common pathways.

There are multiple reasons why medication can be problematic for those with histamine intolerance. Here, I focus on one key aspect: the intricate link between CYP450 medication, inflammation, and histamine.

histamine intolerance, mast cell activation, CYP450, Medicines, Alison Vickery, Health, Australia

Histamine Mechanism

Histamine, an organic compound, is produced by and stored in mast cells and blood basophils.

Two primary mechanisms release histamine: active and passive.

The active mechanism arises from an immune response, like an infection, triggering an organized histamine release without cell death.

The passive mechanism occurs when toxic stimuli damage the cell membrane, causing histamine release as the cell dies.

In both mechanisms, the cell membrane’s integrity significantly impacts histamine release. This integrity is a focus of my health restoration efforts.

Free Radicals

Free radicals, highly harmful to cell membranes, provoke histamine release from mast cells and basophils.

Studies show free radicals interact with cell membranes, triggering histamine release without damaging cells. This occurs during inflammation.

Although harmful, free radicals elicit histamine release without causing cell death. Receptors on the cell membrane recognize free radicals and release histamine.

The immune system produces free radicals to destroy bacteria during infection. These radicals also release histamine, increasing blood flow and attracting white blood cells.

CYP450 Medicines

Medicines metabolised by CYP450 genes, generate free radicals.

Several studies show these free radicals in mast cells provoke histamine release through an active mechanism.

This active mechanism releases histamine without causing cell death, acting as a protective response.

Glutathione and CYP450 Medicines

Studies show natural antioxidants, especially glutathione, protect mast cells from free radical damage and halt histamine release. This suggests that glutathione can improve medication tolerance and prevent histamine release.

The connection between CYP450 medication, inflammation, and histamine is proven. Glutathione offers protection when taking CYP450 medication.

My preferred support method, the LifeWave glutathione patch, demonstrates its efficacy by raising glutathione levels by an impressive 300%.


Understanding the intricate connection between CYP450 medication, inflammation, and histamine is essential for restoring health.

By recognising medicines’ impact on free radicals and the protective role of antioxidants like glutathione, we can better navigate medication risks and benefits.

Supporting our bodies with appropriate measures, such as optimising glutathione levels, can enhance medication tolerance and overall health.

Remember, your healthcare provider is your partner in making informed, safe choices regarding medication use.

Their guidance and your understanding, as shared in my detailed posts and resources, will ensure you can be confident in your healthcare decisions. 

To learn more about the connection between histamine intolerance and medicines, download my free eBook, Histamine Intolerance and Medicines

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Additional Reading