HISTAMINE INTOLERANCE AND GLYPHOSATE

May 18, 2024 2:01 pm

HISTAMINE INTOLERANCE GMO FOODS AND ROUNDUP®

Glyphosate is the active ingredient in Roundup®, a herbicide sold since the 1970s.

This compound is widely used due to its exceptional ability to kill weeds.

Indeed, it is the most-used herbicide worldwide, contaminating crops, drinking water, and the air. Studies show glyphosate residues in the urine of 90% of farmers and a significant portion of the general public. 

Furthermore, since the 1990s, key crops have been genetically modified to resist Roundup®. These key crops include corn, soy, canola, cottonseed, papaya, and sugar beets.

These have widespread implications for our health.

histamine intolerance, Glyphosate, Alison Vickery, Health, Australia

Health Concerns and Regulatory Actions

In 2010, glyphosate was patented as an antibiotic, showcasing its antimicrobial properties (US Patent No. 7771736 B2).

By 2015, the World Health Organisation reclassified it as “probably carcinogenic to humans” but did not ban it. Subsequently, In 2017, the European Union announced that its usage would only be allowed until December 2022, later extending this to December 2023.

Whilst, in June 2020, Bayer, the maker of Roundup®, paid $10 billion to settle non-Hodgkins lymphoma cancer lawsuits.

Despite all these mounting concerns, glyphosate remains widely used. 

Glyphosate

Glyphosate Health Effects

The negative effects of glyphosate on  the body are gradual and result in increasing inflammation and cellular damage. Here is a brief summary of some of the health effects:

Histamine Intolerance

A 2016 study links histamine intolerance with GMO foods and Roundup®-sprayed foods. The study found that GMO maize and glyphosate-sprayed maize contain higher levels of amines and other nutritional differences.

The most notable differences were in amines, including putrescine and cadaverine. These amines increase histamine intolerance by competing for degradation. 

These findings suggest GMO maize and Roundup®-sprayed maize lower the histamine threshold in individuals due to higher amine content.

To lower amines in your diet, it is best to avoid genetically modified and glyphosate-sprayed foods, especially if you struggle with histamine intolerance.

Key strategies to achieve this include buying organic, looking for products labelled “non-GMO,” and avoiding high-risk products such as corn, soy, canola, cottonseed, papaya, sugar beets, and convenience foods. 

By following these steps, you can reduce your intake of amines and improve your histamine intolerance symptoms.

MYTH #1

Glyphosate is safe because it targets a pathway not found in humans

If you have been told this

You probably weren’t told…
This pathway is found in bacteria, including those that make up the human gut microbiome

Glyphosate works by inhibiting an enzyme pathway called the shikimate pathway, which is indeed absent in humans but found in bacteria, including those that make up the human gut microbiome.

The real issue is often fixable with the right knowledge.

I’ve helped hundreds, if not thousands, of people restore their health.

Cotton and glyphosate

Gut Microbiome

Glyphosate was initially developed as an antimicrobial and alters the gut microbiome.

Therefore, it disrupts the gut microbiome, enabling pathogenic bacteria to thrive whilst destroying vital keystone bacteria. This disruption can lead to diseases like IBD and systemic inflammation.

For example, one study examined 101 bacterial species for glyphosate sensitivity and resistance. It found that 54% of gut bacteria species are sensitive to glyphosate, while 29% are potentially resistant.

However, some bacteria, like certain strains of pseudomonas, have adapted to produce enzymes that break down glyphosate. 

In conclusion, there is little doubt that glyphosate disrupts the microbiome and compromises autoimmunity.

Inflammation

Numerous studies show glyphosate exposure increases inflammatory markers and chronic inflammation.

Specfically, tlyphosate disrupts gut microbiota, causing systemic inflammation. This imbalance links closely to lymphoid cancers.

Soy and glyphosate

MYTH #2

Glyphosate is only harmful in large doses:

If you have been told this

You probably weren’t told…

The accumulative effects over time can lead to high levels in the body

While high levels of exposure are certainly more concerning, some research suggests that even low-level exposures to glyphosate can have adverse effects over time

The real issue is often fixable with the right knowledge.

I’ve helped hundreds, if not thousands of people restore their health.

Digestion

Digestion is pH-dependent. Glyphosate affects digestive enzymes and increases fecal pH, disrupting gut bacteria and nutrient absorption.

Key Nutrients

Glyphosate blocks the shikimate pathway in our gut microbiome.

This pathway produces tryptophan, tyrosine, and phenylalanine. Our bodies cannot produce these amino acids, so we must get them from our diet and gut microbes.

These amino acids are vital for many body processes.

Firstly, tryptophan helps build proteins and acts as a precursor to serotonin (which regulates mood, sleep, and appetite), melatonin (which controls the sleep-wake cycle), and niacin (which is essential for metabolism).

Secondly, tyrosine contributes to protein synthesis, leads to dopamine, norepinephrine, and epinephrine (which regulate mood and stress), and is essential for thyroid hormone synthesis.

Thirdly, phenylalanine makes proteins and converts them to tyrosine for further synthesis.

However, the effects of glyphosate do not stop there.

Finally, glyphosate also replaces glycine in the shikimate pathway, disrupting essential bodily functions.

Also, it acts as a chelating agent, making micro-minerals in soil and food non-absorbable, leading to mineral deficiencies that compromise cell function. As such, it can also accumulate in bones and damage kidneys.

Therefore, as glyphosate builds in the body, it has a devastating effect on many key nutrients.

MYTH #3

Eating organic food ensures low glyphosate levels in the body

If you have been told this

You probably weren’t told…
That our environment can be cross-contaminated

Eating organic reduces glyphosate exposure but doesn’t eliminate it, particularly in farming communities due to possible cross-contamination from the water, air, and soil.

The real issue is often fixable with the right knowledge.

I’ve helped hundreds, if not thousands, of people restore their health.

Corn and Glyphosate

Estrogen Disruption

Glyphosate may disrupt the endocrine system by affecting estrogen levels and leading to hormonal imbalances.

Specifically, a review confirmed that glyphosate has characteristics of endocrine disruptors. Endocrine disruptors are compounds that interfere with hormone-receptor connections.

Studies have shown that glyphosate directly binds to estrogen receptors, leading to a disruption in estrogen signalling.

Finally, it alters the gut microbiota, indirectly affecting estrogen metabolism. 

Liver Function

Glyphosate impairs liver detoxification pathways, impacting drug metabolism and increasing the risk of liver damage.

Specifically, glyphosate severely impairs the liver’s detoxification processeses by suppressing phase 1 (cytochrome P450) and phase 2 (sulfation pathway) activities.

Additionally, studies report changes in liver enzymes, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), found on basic blood tests. Elevated levels of these enzymes indicate liver damage.

GMO foods, histamine intolerance, glyphosate, Alison Vickery, Health, Australia

Genetic Modification Implications

Substantial Equivalence and Food Safety

Genetic modification of crops like maize involves inserting bacteria to produce a pesticide in every plant cell. When pests eat the plant, they die.

Whilst, this method makes crop growing more cost-efficient, it raises concerns about human health.

Independent Studies Challenge Equivalance

Firstly, food safety rules require genetically modified crops to have “substantial equivalence” to the original crop.

This term usually means similar macronutrient levels, such as protein, fat, and carbohydrates. It does not consider other differences.

Based on research by GMO crop developers, authorities approved these crops for animal and human consumption as “substantially equivalent.”

Secondly, mounting independent studies show GMO crops are not substantially equivalent.

For instance, a 2016 study found GMO maize and Roundup®-sprayed maize were not equivalent to regular maize. The study revealed significant differences in proteins and metabolites.

It identified 91 proteins and 117 metabolites altered by genetic modification. Suggesting that the GMO crops were not substantially the same.

Histamine intolerance, IBS, IBD, gut health, alison vickery, health, Australia, glyphosate

Strategies for Detoxifying Glyphosate

Humic and Fulvic Acid

Firstly, humic and fulvic acid, found in soil, peat, and various natural sources, have been studied for their potential to interact with glyphosate.  

The products that test well as a preventative include Ion Intelligence of Nature, or for high levels of exposure, Coseva Advanced Fulvic.

Glycine

Secondly, scientific evidence suggests that high doses of glycine may play a crucial role in glyphosate detoxification.

Glyphosate disrupts glutathione production, which is essential for detoxifying various chemicals, including glyphosate itself. 

By providing additional glycine, typically 2 – 5mg, we can counteract glyphosate’s inhibitory effects on glutathione production, thus enhancing glyphosate detoxification.

Roundup Homeopathic

Thirdly, taking Roundup 30C, a homeopathic remedy, trains the body to mobilize glyphosate.

Other Clinical Observations

Ten years ago, I rarely saw high glyphosate levels in my clients. Today, high levels are epidemic.

From my clinical observations, glyphosate has a devastating impact on health. It dramatically affects beneficial bacteria, especially butyrate producers, and is linked to loss of food tolerances. I’ve found that MegaSporeBiotic supports the glyphosate-exposed microbiome.

Furthermore, glyphosate compromises drainage and causes a significant loss of minerals, leading to cell damage. ReMyte Mineral Solution tests well for supporting cell nutrients and helps counteract these effects.

Conclusion

In conclusion, the link between glyphosate and health issues is significant.

This herbicide disrupts beneficial gut bacteria, contributes to inflammation, and interferes with essential nutrients.

Avoiding GMO and glyphosate-sprayed foods can help mitigate these effects. 

However, the prevalence of glyphosate in our environment and its devastating effects means including strategies to protect us from glyphosate is now critical. 

The level of protection will depend on whether the exposure level is high or low. 

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Additional Reading