September 25, 2020 1:01 am

Diamine Oxidase, Histamine Intolerance, Minerals, Vitamins, Alison Vickery, Health, Australia

Here’s some exciting news from a 2017 study! It sheds light on how certain foods can boost diamine oxidase naturally through our diets.

Researchers focused on the macronutrients (protein, fat, and carbohydrates) and micronutrients (essential minerals and vitamins) in healthy women.

They discovered that the overall nutrient quality of our diet—not just the histamine content in foods—greatly affects our histamine-degrading enzyme, diamine oxidase.

By increasing this enzyme, which breaks down excess histamine, we might improve our histamine tolerance.

Below, you’ll find the key nutrients necessary to enhance diamine oxidase levels.

Vitamin C Diamine Oxidase

Vitamin C

Although this study didn’t measure it, Vitamin C is famously known for boosting diamine oxidase. It reduces blood histamine levels and shields cells from oxidative stress.

It’s essential for managing histamine effectively.

Vitamin B6 Histamine Intolerance

Vitamin B6 and Diamine Oxidase

Vitamin B6 plays a pivotal role in more than 100 biochemical reactions in our bodies.

These include boosting plasma levels of diamine oxidase, preventing the release from mast cells, and producing GABA, which helps regulate brain histamine levels.

Clearly, Vitamin B6 is vital for managing histamine levels throughout the body.

Copper and Diamine Oxidase


Copper levels in the body must be carefully managed as they significantly impact histamine intolerance. Both low and high copper levels can affect this condition.

We need copper for diamine oxidase production; thus, supplementing with copper in a multimineral may help when levels are low.

However, excessive copper can mimic estrogen, triggering a cycle where histamine and estrogen perpetuate each other’s production.

When copper is excessively high, binding it with a high dose of rosehip, a natural form of Vitamin C, can be effective.

Olive Oil, Histamine Intolerance, Diamine Oxidase, Alison Vickery, Health, Australia

Long Chain Fatty Acids and Diamine Oxidase

The 2017 study highlighted that long-chain fatty acids, like olive oil, DHA, and EPA, significantly boost diamine oxidase activity. This aligns with earlier research:

A 1998 animal study showed that olive oil increased diamine oxidase levels in a dose-dependent manner.

A 2004 human study revealed that bile replacement, essential for fat digestion and absorption, also raised diamine oxidase levels.

Interestingly, no links were found between carbohydrates, proteins, other fats, overall energy intake, and diamine oxidase levels, nor were they influenced by hormone status.

Although the focus on DHA and EPA might be controversial, based on my experience, it is crucial for managing mast cells and inflammation.

Since publishing this research, I’ve tested products like Zinzino Balance Oil, rich in olive oil, DHA, and EPA, and Zinzino AquaX for those without a gallbladder, on hundreds with histamine intolerance and mast cell activation.

These have performed exceptionally well, even among the most sensitive clients, unlike other DHA and EPA supplements.

Fiber Butyrate


The study revealed no link between fiber intake and diamine oxidase activity, noting that participants consumed low amounts of soluble fiber.

However, earlier research found that seven grams per day of galactomannan for four weeks boosted serum diamine oxidase activity in elderly patients.

Thus, the authors still believe that soluble fiber might enhance these levels.

Furthermore, butyrate, a vital component for stabilizing mast cells, thrives on fiber, underscoring its importance for gut health.

Magnesium Diamine Oxidase

Magnesium and Diamine Oxidase

Magnesium intake is directly linked to diamine oxidase activity. The 2017 findings align with a rat study showing that a lack of dietary magnesium decreased activity levels.

Magnesium levels can quickly deplete due to insufficient magnesium in foods and chronic stress, and it is frequently depleted among my clients.

histamine intolerance, diamine oxidase, nutrients that increase DAO, Alison Vickery, Health, Australia

B12, Zinc, and Other Nutrients

The 2017 study reaffirmed that the menstrual cycle influences diamine oxidase activity. Earlier research showed that this activity is high during pregnancy, drops in the luteal phase when estrogen dominates, and generally affects women more than men.

Significantly, the study found that during the luteal phase (days 15 – 28), the levels of phosphorus, calcium, zinc, magnesium, iron, and vitamin B12 all helped to increase serum diamine oxidase activity.

Clinical Insights into Nutrient Levels

We often overlook that the primary purpose of eating is to supply essential nutrients at the cellular level.

If we lack certain core nutrients, our bodies lack the raw materials needed for vital functions, including the production of diamine oxidase to break down excess histamine.

Vitamins B12, B6, and zinc can vary due to genetic factors.

While issues with methylation and B12 are well-documented, the impact of pyrroles on zinc and vitamin B6 levels is less recognized. Among my clients, 20% had methylation problems, but over 45% faced pyrrole issues.

Additionally, widespread changes in acetylation (B5 levels) and thiamine (B1 levels) are common. These epigenetic alterations in nutrient levels, as part of the cell danger response, are extremely prevalent.


What if we could naturally boost our diamine oxidase levels, without low histamine foods or supplements?

The 2017 study suggests this exciting possibility. It shows that optimizing our diet and improving hormone status can naturally increase our levels. This includes enhancing fat absorption, which is necessary for hormone production.

While moderate deficiencies can often be managed with dietary adjustments, severe deficiencies might still need supplementation.

These typically involve epigenetic changes. This approach offers a holistic and sustainable path to better manage histamine levels and overall health.

To learn more about why olive oil raises diamine oxidase and how fats help with histamine intolerance, check out my blog post, Which Fat Is Low Histamine?

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Additional Reading

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