January 23, 2022 7:00 am

Alison Vickery FDNP, healing, autoimmunity, mast cell activation

The science of healing is advancing rapidly, and Dr. Naviaux’s ground-breaking work sets a robust framework for understanding the body’s healing process.

His concept of the health cycle illustrates that health exists on a spectrum.  At one end, the body naturally maintains and repairs itself—consider how a minor cut heals.

At the other, ongoing cellular damage can lead to disease, where conventional medicine often excels.

This blog post delves into the dynamic nature of the health cycle and the four crucial factors that influence its effectiveness in maintaining our well-being.

Cell Danger Response, Health Cycle

The Four Factors

Circadian Disruption

The healing cycle, including mast cells, operates on circadian rhythms, pre-timed biological processes that dictate active phases during the day and recovery phases at night.

Your healing capacity may diminish if your lifestyle clashes with these rhythms, such as shift work disrupting sleep. Aligning your activities with your body’s natural rhythms is a straightforward and cost-free way to enhance your health.

Glycaemic Dysregulation

Our brain’s ability to switch between glucose, butyrate, and ketones for energy enhances the health cycle.

Specifically, moderate exercise and brief intermittent fasting stress the body, while eating, resting, and sleeping facilitate recovery.

This cycle of regular stress and repair builds our capacity to heal. However, over-stressing an already stressed body won’t aid in healing; only balanced stress that allows for recovery will.

In my client base, rampant issues with blood glucose and insulin reveal that many clients have lost the natural balance between their diet and their body’s needs.

Staying solely in ketosis or undergoing long fasts can also lead to metabolic inflexibility.

Cells have specific nutritional needs, which vary widely among individuals, and often, symptoms arise from poor macronutrient balance in diets rather than the specific foods consumed.

Inflammatory Signals

The body contends with numerous stressors that the health cycle must manage.

These stressors range from heavy metals like mercury and aluminium, chemicals like glyphosate, to biological threats such as parasites, and bacteria, and even food or supplement intolerances.

Prescription medications can also impair mitochondrial function, exemplified by the interaction of certain antihistamines and mast-cell stabilisers with the cell danger response (CDR3).

Addressing these stressors might offer a better strategy for restoring health than merely inhibiting mast cell function.

Perceived Stress

The body often faces hidden emotional stressors that the health cycle must address.

Unresolved mental, intuitive, or spiritual trauma significantly hinders health restoration and often dictates the recovery timeline. Addressing all factors is crucial, but healing cannot be fully achieved without resolving perceived stress.

This approach emphasises the importance of tackling emotional as well as physical health issues to restore health.


Naviaux’s model offers a transformative framework for healing by emphasising the body’s innate ability to heal.

It underscores that health restoration is unattainable without addressing our environment.

The adage “You won’t get well in the same environment you got sick in” captures the essence of this approach, highlighting a departure from traditional medical methods and offering a clear route to regain health. This proactive strategy encourages creating a conducive environment for healing.

To learn more about the other three phases, the cell danger response, read the companion blog post, Cell Danger Response: Rethinking Mast Cell Activation.

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