July 14, 2023 2:19 pm

systmeic enzymes

This blog post is a series of three blog posts looking at the use of enzymes in healing.

This blog post is on systemic enzymes, the next two will be on digestive and other specialized enzymes.

Enzymes are types of proteins that speed up chemical reactions that take place in cells. They play critical roles in many bodily functions.

As we age, our natural production of these enzymes can decrease.

Supplementation then becomes vital to counteract this and provide the body with the enzymes needed to optimize body function.

Systemic enzymes have been utilized in Eastern Medicine for thousands of years. Only recently, have they become a hot topic in Western Medicine.

Yet arguably enzymes are second only to the microbiome in optimizing our health.


Systemic Enzymes

Systemic enzymes are a group of enzymes that work throughout the whole body to support the body’s functions.

Unlike digestive enzymes, which primarily aid in the digestion and absorption of nutrients in the gastrointestinal tract, systemic enzymes are absorbed into the bloodstream, where they work widely throughout the body.

There are three primary types of systemic enzymes in common use today; lumbrokinase, serrapeptase, and nattokinase.

Whilst boluoke®, a type of lumbrokinase, is typically considered the gold standard, it has a price to match. It is also not diluted with other enzymes, unlike many other products.

Nattokinase is 1/36th of the strength of Lumbrokinase, and Serrapeptase 1/294ths. Yet these lesser-strength enzymes often test well in my client base.


Lumbrokinase is an enzyme derived from earthworms that dissolves blood clots and has blood-thinning properties.

Lumbrokinase works by dissolving fibrin and is only active in the presence of fibrin.

Boluoke® is a specific type of lumbrokinase.

Boluoke® has also gone through Phase I to Phase III clinical studies in China, is approved by the Chinese SFDA, and has the longest history of safe clinical use.

Boluoke® and other forms of lumbrokinase are typically useful for blood clotting risks such as atherosclerosis, hypertension, metabolic syndrome, and some viruses.

Here is a summary of the key research:

  1. Coronary Arterial Disease

    Besides lowering blood viscosity, fibrinogen, and ESR (a marker of inflammation), research indicates that lumbrokinase can minimize angina attack frequency.

    Other potential applications of lumbrokinase include deep venous thrombosis, essential hypertension, and vascular dementia.

  2. Prevention and treatment of strokes

    One of the most intensely researched areas is the use of lumbrokinase in the prevention and treatment of strokes.

    Lumbrokinase was shown to be safe and effective for treating acute ischemic stroke by lowering blood viscosity, preventing damage, and reducing neural deficits.

    It was also shown to improve the effectiveness of aspirin as a secondary prevention of strokes.

  3. Post-surgical Adhesion Prevention

    Abdominal surgery carries a significant risk.

    A 2023 study in the BioMed Research journal concluded that lumbrokinase supports wound healing and significantly decreased the severity and the area of intra-abdominal adhesion.

Lumbrikonase is not suitable for everyone. Contraindications include:

  1. Blood-thinning Medication

    People taking anticoagulant or antiplatelet drugs, including aspirin, warfarin (Coumadin), heparin, clopidogrel (Plavix), and others, should not take Boluoke® unless supervised by a healthcare provider.

  2. Surgery

    It should be discontinued at least two weeks before any surgical procedure, including dental procedures, to prevent excessive bleeding.

  3. Pregnancy and Breastfeeding

    The safety of lumbrokinase during pregnancy and breastfeeding has not been established. Women who are pregnant, trying to become pregnant, or breastfeeding should avoid it.

  4. Bleeding Disorders

    People with bleeding disorders or a history of stroke may be at a higher risk of bleeding while taking lumbrokinase.

In my client base, Boluoke® regularly tests when there is severe inflammation from viruses.


Similar to Boluoke®, serrapeptase is an enzyme extracted from silkworms.

It too has been used for years in Japan and Europe as an anti-inflammatory for pain and swelling.

Researchers consider serrapeptase to be the most effective enzyme for reducing inflammation.

Here are some key research findings:

  1. Anti-inflammatory properties

    Serrapeptase has been found to have anti-inflammatory properties, which can help to reduce swelling, pain, and inflammation in the body.

  2. Pain relief

    Serrapeptase may help relieve pain by reducing inflammation and breaking down proteins contributing to pain and swelling for example with osteoarthritis and after an injury.

  3. Improved circulation

    Serrapeptase may help improve circulation by breaking down fibrin, a protein contributing to blood clot formation.

    As such it is thought to be helpful in treating the build-up of fats, cholesterol, and other harmful substances inside arterial walls.

  4. Improved respiratory function

    Serrapeptase may help to improve respiratory function by breaking down mucus and reducing inflammation in the airways for example with chronic obstructive pulmonary disease (COPD) and chronic bronchitis.

Serrapeptase frequently tests well for pain and inflammation in my client base.

A large percentage of my client base has Bartonella which causes extreme intestinal permeability and the resulting pain and inflammation throughout the body. Serrapeptase can be extremely helpful in these circumstances whilst working on the underlying root cause.


Nattokinase is an enzyme derived from fermented soybeans that has anti-inflammatory properties.

Here are some key research findings:

  1. Anti-inflammatory properties

    Nattokinase has been found to have anti-inflammatory properties, which may help to reduce inflammation in the body.

  2. Cardiovascular health

    Nattokinase may help to lower blood pressure and reduce the risk of blood clots.

  3. Improved circulation

    Nattokinase has been shown to help to dissolve fibrin, a protein that contributes to blood clot formation. This can improve circulation and reduce the risk of heart disease.

  4. Improved cognitive function

    Nattokinase may have a protective effect on the brain. A study published in Brain Research found that nattokinase reduced brain damage in rats.

Nattokinase also tests well particularly where a client has high blood pressure. I have seen this normalize blood pressure whilst working on the underlying root cause.


Systemic enzymes are playing an increasing role in my client protocols.

I use autonomic response testing in my client base to determine which systemic enzyme is needed, however, as a general rule, serrapeptase tends to test well for inflammation and pain, whilst nattokinase and lumbrokinase are more suited for blood clotting and cardiovascular issues.

The use of enzymes to dissolve scars and thickening of tissue is also an exciting potential use.

I have observed one client dissolve the thickening of her uterus wall with systemic enzymes, and another dissolve a scar post-abdominal surgery.

As the knowledge of systematic enzymes finds its way into Western medicine the uses are likely to become much more widely spread.



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