November 29, 2021 9:00 pm

Alison Vickery

Vitamin C is a simple and effective antihistamine. Not to mention, it is a vital nutrient needed to perform many bodily functions.  Here is what you need to know.

Natural Antihistamine

Vitamin C deficiency, widely known for causing scurvy, is also a natural antihistamine.

That is, a deficiency in this essential nutrient can cause a cascade of histamine intolerance issues, including;

  • Firstly, histamine intolerance,
  • Secondly, diamine oxidase deficiency (the enzyme that degrades histamine),
  • Thirdly, elevated blood histamine levels,
  • Fourthly, increased histamine neurotransmitters, and
  • Lastly, compromised immune function.

This underscores the importance of vitamin C as an antihistamine.

Key Benefits

Adequate vitamin C intake has numerous vital benefits that enhance various aspects of health:

Firstly, Improved Histamine Regulation: It is a co-factor in regulating histamine levels and ensuring ythe body responds appropriately to allergens and inflammation. 

Next, Oxidative Stress Reduction: As a potent free radical scavenger, vitamin C effectively neutralises oxidative stress. This action is essential in protecting lipids, DNA, and RNA from damage, thus preserving cellular health.

Then, Collagen Health and Protection: It plays a pivotal role in the maintenance and repair of collagen-rich tissues such as skin, bones, cartilage, ligaments, and tendons and guards against photo-damage.

Next, Improved Immune Function: Vitamin C is crucial for the optimal functioning of white blood cells, including neutrophils, which combat infections.

Then, Improved Cognitive Function: It enhances concentration and performance on tasks that require attention, focus, and working memory.

Next, Brain Health: It regulates and balances neuronal activity and shields the brain from oxidative stress.

Then, Genetic Regulation:  It shields genes genes from environmental stressors, playing a protective role at the cellular level.

Finally, Cardiovascular Health: It can reduce the risk of cardiovascular disease. Specifically, it supports the integrity of blood vessels, reduces vascular free radical damage, and improves microcirculation, promoting heart health and vascular function.

This underscores the importance of vitamin C levels to overall health and well-being.

Vitamin C, Natural Antihistamine

Vitamin C Deficiencies

Vitamin C deficiencies stem primarily from two root causes:

Firstly, A Poor Diet: If your diet lacks fresh fruits and vegetables rich in vitamin C, you’re at risk of deficiency. Unlike some animals, humans cannot synthesise it internally; thus, obtaining it through dietary sources is essential.

Secondly, Increased Demand: Various factors can escalate your body’s need for vitamin C. These include cellular stress caused by viruses, high levels of physical activity, physical illnesses, and exposure to toxins.

Consequently, maintaining adequate vitamin C levels is not only an antihistamine but is crucial for overall health.

Furthermore, the more chronic the condition, the greater the vitamin C depletion, highlighting this nutrient’s importance in managing health issues.

Testing Levels

To determine your vitamin C status, a simple blood test measuring plasma ascorbate is effective:

In Australia, I utilise  iMedical to assess blood plasma levels. For the test to yield reliable results, it should be conducted fasting, with no vitamin C consumption for 12 hours prior.

Additionally, I recommend the Vibrant Wellness Dried Spot Micronutrients Test. This test is accessible globally and costs approximately US$200.

It offers a comprehensive analysis, providing a broad spectrum of nutrient markers, making it a valuable tool for a detailed nutritional assessment.

vitamin c, kakadu plum, natural antihistamine

Restoring Vitamin C Levels

Restoring vitamin C levels generally begins with ensuring our diet includes sufficient fruits and vegetables.

However, when ill health significantly increases the demand for vitamin C, and we want to use it as an anti-histamine, additional food sources become necessary.

Extremely high levels can be found in:

  • Firstly, Kakadu Plum (Gubinge): Native to Australia, the Kakadu plum boasts the highest concentration of vitamin C of any food. Just 15 grams of this fruit provides an impressive 2 grams of vitamin C.

  • Secondly, Camu Camu: This fruit, native to Peru, is second only to Kakadu plum. Consuming just 17 grams of Camu Camu delivers 2 grams of vitamin C. Its consistency and taste are similar to that of Kakadu plum, making it a viable alternative.

  • Thirdly, Rosehips: Although they contain less than Kakadu plum or Camu Camu, rosehips are rich in antioxidants and flavonoids. They are particularly effective as a binder for high copper levels and can dramatically reduce them to a normal range.

  • Finally, Aloe Vera: has been shown to enhance the gastric absorption of vitamin C by up to 300%. 

Incorporating these potent sources into your diet can boost your vitamin C levels and support a broader spectrum of health benefits.


Vitamin C can be used therapeutically to manage chronic conditions.

Below is a concise summary of current research findings for adult dosage recommendations:

  • General Health: Aim for 200 milligrams daily, especially if dietary intake is insufficient.

  • Histamine Intolerance: 1 to 3 grams daily is advisable, with 2 grams typically recommended, as an antihistamine.

  • Diabetes or Suppressed Immune System: At least 6 grams daily is necessary for effective management.

  • Active Bacterial, Viral, Flu, or UTI Infections: Start with an initial dose of 3 grams, followed by 1 to 2 grams every hour for 6 to 8 hours.

  • Mild COVID Infections: Begin with 3 grams, then continue with 1 to 2 grams every hour for 6 to 8 hours until symptoms subside. Once symptoms improve, maintain a dosage of 8 to 12 grams daily for at least two weeks.

  • Severe COVID Infections: Start with 3 to 5 grams, followed by 2 grams every 30 minutes for the first 4 hours. If symptoms persist, administer 3 to 5 grams, then 2 grams every 30 minutes for another 12 hours. If there’s still no improvement, increase to 10 grams, followed by 3 to 5 grams every 30 minutes for 12 hours. Subsequently, transition to the regimen recommended for mild COVID-19 infections.

Frequent, small doses are generally more effective than a single large dose.

If gut health is compromised, consider liposomal or intravenous forms that bypass the gastrointestinal tract, which may provide better absorption and effectiveness.

By strategically adjusting vitamin C intake based on specific health needs and conditions, individuals can significantly enhance their body’s ability to recover and maintain optimal health.

Ascorbic Acid

Vitamin C Precautions

Vitamin C is generally safe to use, though there are a few notable exceptions to consider:

  • Firstly, Hemochromatosis: In individuals with hemochromatosis, it can increase iron absorption, potentially leading to iron-induced oxidative damage due to the excess iron.

  • Secondly, Oxalate Intolerance: Consuming high amounts of oxalate increases the risk of developing oxalate stones in those with oxalate intolerance or compromised kidney function.

  • Thirdly, Glucose 6-phosphate Dehydrogenase Deficiency: This genetic disorder can heighten the risk of issues related to red blood cells.

  • Finally, Diarrhea: While vitamin C is not toxic, excessive intake beyond what the intestines can absorb may lead to diarrhea. If this occurs, lower the dosage or change to liposomal or intravenous forms. 

Overall, with awareness of individual circumstances, vitamin C remains a remarkably safe and beneficial nutrient for most people.


Along with zeolite, I often turn to Vitamin C as one of my go-to antihistamines for managing histamine intolerance and promoting overall health restoration.

Instead of defaulting to antihistamines, which merely block your body’s natural responses, consider boosting your vitamin C intake.

Doing so gives your body the essential raw materials it needs to function optimally, as nature intended. This proactive approach addresses the symptoms and supports your body’s inherent healing processes.

To learn more about natural antihistamines that help with histamine intolerance, check out my blog post, Natural Antihistamine.

Follow me on InstagramFacebook, and YouTube to continue the conversation.

Additional Reading

Johnston, C. S. (1996). The antihistamine action of ascorbic acid. In Sub-cellular Biochemistry (pp. 189-213). Springer US.

Hagel, Alexander F., et al. “Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases.” Naunyn-Schmiedeberg’s archives of pharmacology 386.9 (2013): 789-793.

Jarish, R, Editor (2015). Histamine Intolerance: Histamine and Seasickness.

Nandi, B. K., et al. “Effect of ascorbic acid on detoxification of histamine under stress conditions.” Biochemical pharmacology 23.3 (1974): 643-647.

How Vitamin C Works

Panush, R. S., et al. “Modulation of certain immunologic responses by vitamin C. III. Potentiation of in vitro and in vivo lymphocyte responses.” International journal for vitamin and nutrition research. Supplement= Internationale Zeitschrift fur Vitamin-und Ernahrungsforschung. Supplement 23 (1982): 35-47.

Elste, Volker, et al. “Emerging evidence on neutrophil motility supporting its usefulness to define vitamin C intake requirements.” Nutrients 9.5 (2017): 503.

Hemilä, Harri. “Vitamin C and infections.” Nutrients 9.4 (2017): 339.

Harrison, Fiona E., and James M. May. “Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2.” Free Radical Biology and Medicine 46.6 (2009): 719-730.

Li, Yi, and Herb E. Schellhorn. “New developments and novel therapeutic perspectives for vitamin C.” The Journal of nutrition 137.10 (2007): 2171-2184.