Over the last year or so, I have been using zeolite, rather than prescription medication, to successfully detoxify mold.

Since then I have discovered that zeolite binds histamines, providing another way to neutralize excess histamines in the gastrointestinal tract.

Once I stumbled onto this discovery, I have used zeolite to rapidly reducing any histamine reactions.

So much so that rather than reaching for an anti-histamine I now reach for zeolite. My last histamine attack was resolved within 30 minutes.


Zeolite is a natural clay-like substance, that has a honeycomb-like structure, that absorbs into its pores, selective ingredients.

Zeolite is a class of mineral which is then classified into subtypes of zeolite based on its properties. There are more than 50 natural zeolites.

Clinoptilolite is the subtype with health benefits.

And Clinoptilolite with a silica/aluminum ratio (which needs to be above 5 to also ensure no Aluminum is absorbed) determines its effectiveness.

ZeolithMed has a ratio of 5.4:1. Toxaprevent, and Biopure Zeobind also have a good silica/alumium ratio.

Zeolite Binds Histamine

Histamine Intolerance

The human body is designed to process or deactivate histamines by using diamine oxidase enzymes to alter histamines so they cannot be reabsorbed in the intestinal mucosa.

Diamine oxidase (DAO) enzymes in the intestinal tracts chemically alter histamines or deactivate them so they cannot be reabsorbed and circulate throughout the body.

However, that process is limited. When there is too little diamine oxidase being made, or too many histamines circulating, the body cannot keep up with demand.

However, Zeolite jumps over that limitation.

It simply binds up histamine in the gastrointestinal tract, hides histamine away from the body in its porous cavities, and directly eliminates it via the stool. It bypasses the DAO, HNMT, and MAO regulatory systems altogether.

As it works on the gastrointestinal tracts it does not address histamine in the blood which is a marker of methylation issues.

Here are just a few of the ways that zeolite has been found to help histamine degradation.

High Histamine Foods

Digested histamines are strongly bound to zeolite when consumed within 30 minutes of food. Indeed, studies show that up to 82% of ingested histamines are bound.


A small human study has demonstrated that zeolite significantly reduces the effects of alcohol consumption (but not blood alcohol levels).

Diamine Oxidase

A small animal study found zeolite was protective of diamine oxidase levels and intestinal barrier function.

Leaky Gut

A substantial human study of zeolite supplementation found a 30% improvement in zonulin (a marker of intestinal integrity).

There was no significant change in the status of key nutrients.

A 2017 animal study, also found that zeolite resulted in significant improvements in the gut villus (height, perimeter, section area) in the gut mucosa.

There is evidence that zeolite reinforces or coats the mucosal barrier and improve intestinal wall integrity.

Inflammatory Bowel Disease

Leaky gut is thought to be a crucial step in the development of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.

A 2018 animal study, found that zeolite reduced gut inflammation and that an inflamed gut can be exposed to zeolite for a prolonged period of time.


The outer cell wall of gram-negative bacteria contains pro-inflammatory lipopolysaccharides which are known to activate mast cells.

In an animal study, zeolite acted as an anti-inflammatory, preventing lipopolysaccharides from stimulating a variety of inflammatory markers, and regulated the immune system.

Other Health Benefits of Zeolite

Zeolite, and specifically clinoptilolite, is an intelligent binder.

It only attaches to harmful substances and does not alter trace elements, minerals, or vitamins, even with long-term use.

Zeolite Histamine

Other than excess histamine, clinoptilolite has been shown to bind the following toxins:

  • Heavy metals (other binders can be more selective),
  • Viruses,
  • Some pathogenic bacteria, Escherichia coliBacillus subtilis, Staphylococcus aureus, Salmonella, Streptococcus mutans, Streptococcus mitis, and Pseudomonas aeruginosa,
  • Ammonia - which is necessary for H.Pylori to thrive (Zeolite has been shown to inhibit h.pylori by starving it of ammonia)
  • Fungal toxins,
  • Radioactive materials,
  • Flouride.

Other health benefits of clinoptilolite include restoration of the body's reserves of anti-oxidants, minerals, and the microbiome which would otherwise be used for detoxification.

How To Use Zeolite

There are 50 types of zeolite in nature.

Not all forms of zeolite work in the same way, because of their size, chemical structure, or purity.

The type of zeolite needed is clinoptilolite and one with a high silica to aluminum ratio.

Because of the wide variety in types of zeolite, I also like products to be tested for their histamine binding capacity.

The product that I use is Zeolith MED as it has been specifically tested, and bind to 83.5% of all histamines in the gastrointestinal tract.

So far, other than Toxaprevent®, I have not been able to identify other zeolites with histamine testing.

I have also been frequently asked about the liquid forms of zeolite on the market. These do not bind histamines in the gastrointestinal tract rather they work intra-cellularly.

I have been using Vitality Detox Drops to detoxify mold intra-cellularly, and then ZeolithMed  (and more recently Toxaprevent®) to bind up the mold in the gastrointestinal tract.

I am not aware of other brands, that have the right silica to aluminum ratio, or that have been adequately tested.

When using zeolite, it is important to use a wooden or plastic spoon to stir the zeolite, as a metal one can change its charge, making it less effective at pulling out toxins.

Needless to say, it is also important to ensure that any constipation is resolved or managed. Having bound up the histamine, it needs to be excreted, otherwise, it will be reabsorbed.

Also if you have low stomach acid, then you may not be able to break down the powder form, in which case capsules are usually better tolerated.


Zeolite has become a part of my core protocol, is a core part of Dr. Klinghardt's protocol, and I am including it more and more in client protocols.

Not only has it a lot of clinical experience in detoxifying histamines but it also has a mounting body of research. It is well tolerated and is virtually tasteless.

What's more, it seems such a simple, almost genius, solution to histamine problems.

Please consult your physician before trialing this product. I am providing this information based on my own exceptional personal experiences and in order for you to open a conversation with your own healthcare provider.

Additional References

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Kraljevi  Paveli  Sandra, et al. "Critical review on clinoptilolite safety and medical applications in vivo." Frontiers in Pharmacology 9 (2018): 1350.

Selvam, Thangaraj, Wilhelm Schwieger, and Wilfried Dathe. "Histamine-binding capacities of different natural zeolites: a comparative study." Environmental geochemistry and health(2018): 1-9.

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Influence of CLINOPTILOLITE and MANC® on the natural balance of micro nutrients, FEB-03-2016.

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Valpoti?, Hrvoje, et al. "Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations." Periodicum biologorum 119.3 (2017): 159-172.


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