Over the last year or so, I have been using zeolite, rather than prescription medication, to successfully detoxify mold.

Since then I have discovered that zeolite binds histamines, providing another way to neutralize excess histamines in the gastrointestinal tract.

Once I stumbled onto this discovery, I have used zeolite to rapidly reduce any histamine reactions.

So much so that rather than reaching for an anti-histamine I now reach for zeolite. My last histamine attack was resolved within 30 minutes.


Zeolite is a natural clay-like substance, that has a honeycomb-like structure, that absorbs into its pores, selective ingredients.

Zeolite is a class of minerals that are then classified into subtypes of zeolite based on their properties. There are more than 50 natural zeolites.

Clinoptilolite is the subtype with health benefits.

And Clinoptilolite with a silica/aluminum ratio (which needs to be above 5 to also ensure no Aluminum is absorbed) determines its effectiveness.

Toxaprevent, and Biopure Zeobind also have a good silica/aluminum ratio. Please note that I no longer use or recommend Zeolith Med. 

Zeolite Binds Histamine

Histamine Intolerance

The human body is designed to process or deactivate histamines by using diamine oxidase enzymes to alter histamines so they cannot be reabsorbed in the intestinal mucosa.

Diamine oxidase (DAO) enzymes in the intestinal tracts chemically alter histamines or deactivate them so they cannot be reabsorbed and circulate throughout the body.

However, that process is limited. When there is too little diamine oxidase being made, or too many histamines circulating, the body cannot keep up with demand.

However, Zeolite jumps over that limitation.

It simply binds up histamine in the gastrointestinal tract, hides histamine away from the body in its porous cavities, and directly eliminates it via the stool. It bypasses the DAO, HNMT, and MAO regulatory systems altogether.

As it works on the gastrointestinal tracts it does not address histamine in the blood which is a marker of methylation issues.

Here are just a few of the ways that zeolite has been found to help histamine degradation.

High Histamine Foods

Digested histamines are strongly bound to zeolite when consumed within 30 minutes of food. Indeed, studies show that up to 82% of ingested histamines are bound.


A small human study has demonstrated that zeolite significantly reduces the effects of alcohol consumption (but not blood alcohol levels).

Diamine Oxidase

A small animal study found zeolite was protective of diamine oxidase levels and intestinal barrier function.

Leaky Gut

A substantial human study of zeolite supplementation found a 30% improvement in zonulin (a marker of intestinal integrity).

There was no significant change in the status of key nutrients.

A 2017 animal study, also found that zeolite resulted in significant improvements in the gut villus (height, perimeter, section area) in the gut mucosa.

There is evidence that zeolite reinforces or coats the mucosal barrier and improves intestinal wall integrity.

Inflammatory Bowel Disease

Leaky gut is thought to be a crucial step in the development of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.

A 2018 animal study, found that zeolite reduced gut inflammation and that an inflamed gut can be exposed to zeolite for a prolonged period of time.


The outer cell wall of gram-negative bacteria contains pro-inflammatory lipopolysaccharides which are known to activate mast cells.

In an animal study, zeolite acted as an anti-inflammatory, preventing lipopolysaccharides from stimulating a variety of inflammatory markers, and regulating the immune system.

Other Health Benefits of Zeolite

Zeolite, more specifically clinoptilolite, is an intelligent binder.

It only attaches to harmful substances and does not alter trace elements, minerals, or vitamins, even with long-term use.

Zeolite Histamine

Other than excess histamine, clinoptilolite has been shown to bind the following toxins:

  • Heavy metals (other binders can be more selective),
  • Viruses,
  • Some pathogenic bacteria, Escherichia coliBacillus subtilis, Staphylococcus aureus, Salmonella, Streptococcus mutans, Streptococcus mitis, and Pseudomonas aeruginosa,
  • Ammonia - which is necessary for H.Pylori to thrive (Zeolite has been shown to inhibit h.pylori by starving it of ammonia)
  • Mould toxins,
  • Radioactive materials,
  • Flouride.

Other health benefits of clinoptilolite include restoration of the body's reserves of antioxidants, minerals, and the microbiome which would otherwise be used for detoxification.

How To Use Zeolite

There are 50 types of zeolite in nature.

Not all forms of zeolite work in the same way, because of their size, chemical structure, or purity.

The type of zeolite needed is clinoptilolite and one with high silica to aluminum ratio.

Because of the wide variety of types of zeolite, I also like products to be tested for their histamine binding capacity.

The product that I use is Toxaprevent as it has been specifically tested, and binds to over 80% of all histamines in the gastrointestinal tract.

I have also been frequently asked about the liquid forms of zeolite on the market. These do not bind histamines in the gastrointestinal tract rather they work intra-cellularly.

These liquid forms of zeolite, refuse to disclose their ratio of silica, or that have been adequately tested.

When using zeolite, it is important to use a wooden or plastic spoon to stir the zeolite, as a metal one can change its charge, making it less effective at pulling out toxins.

Needless to say, it is also important to ensure that any constipation is resolved or managed. Having bound up the histamine, it needs to be excreted, otherwise, it will be reabsorbed.

Also if you have low stomach acid, then you may not be able to break down the powder form, in which case capsules are usually better tolerated.


Zeolite has become a part of my core protocol, is a core part of Dr. Klinghardt's protocol, and I am including it more and more in client protocols.

Not only has it a lot of clinical experience in detoxifying histamines but it also has a mounting body of research. It is well tolerated and is virtually tasteless.

What's more, it seems such a simple, almost genius, solution to histamine problems.

Please consult your physician before trialing this product. I am providing this information based on my own exceptional personal experiences in order for you to open a conversation with your own healthcare provider.

Additional References

Farina, Mauro, et al. "Antibacterial activity of Na-clinoptilolite against Helicobacter pylori: in-vitro tests, synergistic effect with amoxicillin and stability of the antibiotic formulated with the zeolite." Microporous and Mesoporous Materials 288 (2019): 109592.

Kraljevi  Paveli  Sandra, et al. "Critical review on clinoptilolite safety and medical applications in vivo." Frontiers in Pharmacology 9 (2018): 1350.

Selvam, Thangaraj, Wilhelm Schwieger, and Wilfried Dathe. "Histamine-binding capacities of different natural zeolites: a comparative study." Environmental geochemistry and health(2018): 1-9.

Dacewicz, Ewa. "Application of Selective and Porous Materials for the removal of biogenic compounds and indicator bacteria from domestic wastewater." ACTA Scientiarum-Formatio circuiectus 17.2 (2018): 47-55.

Gokdogan, Saadet, et al. "The influences of natural zeolite (clinoptilolite) on ammonia and biogenic amine formation by foodborne pathogen." Journal of food science 77.8 (2012): M452-M457.

Bacakova, Lucie, et al. "Applications of zeolites in biotechnology and medicine–a review." Biomaterials Science(2018).

Nizet, Stéphane, et al. "Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation." Inflammatory Bowel Diseases24.1 (2017): 54-66.

Wawrzyniak, A., et al. "Effect of Feeding Transcarpathian Zeolite on Gastrointestinal Morphology and Function in Broiler Chickens." Revista Brasileira de Ciência Avícola 19.4 (2017): 737-746.

Steimecke, Günter, Steffen Hoffmann, and Thomas Görner. "Method for the reduction of the concentration of amines and salts thereof." U.S. Patent No. 8,951,549. 10 Feb. 2015.

Selvam, T., W. Schwieger, and W. Dathe. "Natural Cuban zeolites for medical use and their histamine binding capacity." Clay Minerals 49.4 (2014): 501-512.

Lamprecht, Johan C., et al. "The effects of an artificially enhanced clinoptilolite in patients with irritable bowel syndrome." South African Family Practice 59.1 (2017): 18-22.

Lamprecht, Manfred, et al. "Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redox biology and performance in aerobically trained subjects." Journal of the International Society of Sports Nutrition 12.1 (2015): 40.

Gandy, Justin John, Ilze Laurens, and Jacques Rene Snyman. "Potentiated clinoptilolite reduces signs and symptoms associated with veisalgia." Clinical and experimental gastroenterology 8 (2015): 271.

Özogul, Fatih, Imen Hamed, and Saadet Gokdogan. "The impact of natural clinoptilolite on ammonia, cadaverine and other polyamine formation by the foodborne pathogen in lysine decarboxylase broth." LWT-Food Science and Technology 65 (2016): 703-710.

Ozogul, Fatih, et al. "Effect of natural zeolite (clinoptilolite) on in vitro biogenic amine production by Gram-positive and Gram-negative pathogens." Frontiers in Microbiology 9 (2018): 2585.

Gokdogan, S., Özogul, Y., Kuley, E., Özogul, F., Kacar, C., and Ucar, Y. (2012). The influences of natural zeolite (clinoptilolite on ammonia and biogenic amine formation by food-borne pathogen. J. Food Sci. 77, M452–M457. doi: 10.1111/j.1750-3841.2012.02822.x

Kubota, Munehiro, et al. "Selective adsorption of bacterial cells onto zeolites." Colloids and Surfaces B: Biointerfaces 64.1 (2008): 88-97.

Kuley, Esmeray, et al. "The impact of applying natural clinoptilolite (zeolite) on the chemical, sensory and microbiological changes of vacuum-packed sardine fillets." International journal of food science & technology 47.9 (2012): 1977-1985.

Danz, Hubert, et al. "Use of an activated zeolite as a pharmaceutical agent for reducing toxic substances." U.S. Patent Application No. 12/092,460.

Wu, Qiu Jue, et al. "The effects of natural and modified clinoptilolite on intestinal barrier function and immune response to LPS in broiler chickens." Veterinary immunology and immunopathology 153.1 (2013): 70-76.

Ivkovic, Slavko, et al. "Dietary supplementation with the tribomechanical activated zeolite clinoptilolite in immunodeficiency: effects on the immune system." Advances in therapy 21.2 (2004): 135-147.

Varel, Vincent H., I. M. Robinson, and W. G. Pond. "Effect of dietary copper sulfate, Aureo SP250, or clinoptilolite on urealytic bacteria found in the pig large intestine." Applied and environmental microbiology 53.9 (1987): 2009-2012.

Laurino C, Palmieri B. Zeolite: The Magic stone: Main nutritional, environmental, experimental and clinical fields of application. Nutr Hosp. 2015 Aug 1;32(2):573-81.

Influence of CLINOPTILOLITE and MANC® on the natural balance of micronutrients, FEB-03-2016.

Albengres, E., et al. "Interactions between smectite, a mucus stabilizer, and acidic and basic drugs." European journal of clinical pharmacology 28.5 (1985): 601-605.

Papaioannou, D. S., et al. "Effect of in-feed inclusion of a natural zeolite (clinoptilolite) on certain vitamin, macro and trace element concentrations in the blood, liver and kidney tissues of sows." Research in veterinary science 72.1 (2002): 61-68.

Katsoulos, Panagiotis D., et al. "Effect of long-term dietary supplementation with clinoptilolite on performance and selected serum biochemical values in dairy goats." American journal of veterinary research 70.3 (2009): 346-352.

Katsoulos, P. D., Roubies, N., Panousis, N., Arsenos, G., Christaki, E., and Karatzias, H. (2005a). Effects of long-term dietary supplementation with clinoptilolite on incidence of parturient paresis and serum concentrations of total calcium, phosphate, magnesium, potassium, and sodium in dairy cows. Am. J. Vet. Res. 66, 2081–2085.

Katsoulos, P. D., Roubies, N., Panousis, N., and Karatzias, H. (2005b). Effects of long-term feeding dairy cows on a diet supplemented with clinoptilolite on certain serum trace elements. Biol. Trace Elem. Res. 108, 137–145.

Katsoulos, P. D., Karatzia, M. A., Boscos, C., Wolf, P., and Karatzias, H. (2016). In-field evaluation of clinoptilolite feeding efficacy on the reduction of milk aflatoxin M1 concentration in dairy cattle. J. Anim. Sci. Technol. 58, 1–7. doi: 10.1186/s40781-016-0106-4.

Flowers, James L., Stewart A. Lonky, and Erik J. Deitsch. "Clinical evidence supporting the use of an activated clinoptilolite suspension as an agent to increase urinary excretion of toxic heavy metals." Nutrition and Dietary Supplements 1 (2009): 11-18.

Basha, Mahaboob P., Shabana Begum, and Bilal Ahmed Mir. "Neuroprotective actions of clinoptilolite and ethylenediaminetetraacetic acid against lead-induced toxicity in mice Mus musculus." Toxicology international 20.3 (2013): 201.

Federico, A., et al. "A pilot study on the ability of clinoptilolite to absorb ethanol in vivo in healthy drinkers: Effect of gender." J. Physiol. Pharmacol 66 (2015): 441-447.

Jung, S. B., et al. "Association between vitamin B 12 deficiency and long-term use of acid-lowering agents: a systematic review and meta-analysis." Internal medicine journal 45.4 (2015): 409-416.

Cutovic, Milisav, et al. "Clinoptilolite for treatment of dyslipidemia: preliminary efficacy study." The Journal of Alternative and Complementary Medicine 23.9 (2017): 738-744.

Valpoti, Hrvoje, et al. "Zeolite clinoptilolite nanoporous feed additive for animals of veterinary importance: potentials and limitations." Periodicum biologorum 119.3 (2017): 159-172.


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